I've been on Letrozole for 18 months post bi-lateral mastecomy, and 8 rds of CMF. Diagnosed w/invasive BC, also have Brac 1 gene. Presently 60 yrs old, and since this journey began I've gone from a very healthy, active woman who only took EsterC and Multi Vitamin, to taking daily meds. Presently on Letrozole 2.5 (just recently learned there are different brands), have lymphedema in my arm (Dr's surprised as I had only breast nodes removed. Also have l a abdominal swelling of fluids on my m right side. (Dr's have not explainations on that.) I do go to P/t for swelling which seems to help. Have vaginal bleeding (have not had period since age 40) after/during workouts, long vigorous walks (solution was a vaginal cream, after 12 months, no change, now wear mini pads) Blood pressure slowly rising. Went from BP110/70 to 145/85. I know not high but according to all I've read pre hypertension. In the last 3 months chronic UTI.(been on antibotics 3x) Along with severe skeletal pain (I take magnesium 250 mg) Finally put all together after reading side effects of Letrozole, and all of my issues are listed. Went to my Onco to discuss a solution. After much pushing by me, she agreed to pull me off, well for two weeks. Three days post, my arm/abdomial swelling greatly reduced. No muscle aches, no bleeding. Wondering if others have similar journey or if there are alternatives?
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I too, am using Letrozole, and only thru reading posts was I made aware that there are different brands. I don't know what brand mine is, probably generic as all it states is "Letrozole". I've been on L, since 10/15. Experienced extreme bone aches, skeletal pain so intense as well as extreme leg cramps. I did a little research and found my magnesimun levels were low. Having 2 sisters w/medical issues and taking magnesium, I on my own began taking 250mgs daily. Within a week, no pain. I shared this w/ my Oncologist. She encouraged me to continue, as it was not interacting negatively. The fatiuge is another issue. I have not been able to solve that. I was a very active person, I rode my horse daily for 3- 5 hrs w/o being or feeling tired. Now I am lucky to get a ride in longer then 2 hrs, as I have to have ability to drive the 40 minutes home. Fatigue when it hits, it hits. My other side effects are fluid retention on my right side of my abdomin, thats right just the right side, vaginal bleeding, and the most annoying is chronic UTI's. Finally had enough, put all my issues on the table, as well as a creeping b/p, which was normally 110/70, and which is not 145/80, and presented to Oncologist. She has not answers, only responds "you're Cancer free". Pressed my issues and now off Letrozole for 2 weeks. Three day, yes 3 day off, and I am a new person. Fluid retention down, no bleeding, (still on antibotics for UTI, so don't know there). Looking for alternatives or maybe nothing. My cancer was invasive BC, had bi-lateral mastecomy, 8 rounds of CMF.
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