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Re-biopsy

4 REPLIES
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Member

Re: Re-biopsy

Hi Nicky, they really are crafty b*****s aren’t they? xx
Member

Re: Re-biopsy

Hi Plasem

I hope you get the answer you need soon xx

Member

Re: Re-biopsy

I had one biopsy of my rib bone when I was diagnosed with MBC and they couldn’t not get the right specimen so it was negative I would like to have another because I think my medicine stopped working but I am afraid because I am prone to infection
Community Champion

Re: Re-biopsy

Hi

Yes, mine has changed over the years - I think I’ve  probably said this on the liver resection thread.

My primary was ER and PR + (HER2 wasn’t routinely tested for in 2003). A local recurrence was also the same in 2008 and that sample and the original tissue from 2003 was tested for HER2 and I was negative for HER2. After liver mets showed up in 2013 I had a biopsy and it showed triple positive. Another liver biopsy in 2016 also showed triple positive. However the liver resection gave a larger sample to check and in fact the lesion that had always behaved completely differently to any other met (and had been biopsied on 2 occasions) was triple negative. Having had that removed my mets should all be back to hormone positive, HER 2 negative.

Nicky x

Member

Re-biopsy

Has anyone had their secondary BC re-biopsied after treatment failure?

 

I was originally triple positive (July 17) and now after Herceptin & Pertuzamab (after 11 months) and Kadcyla (after 2 cycles) have stopped working, with progression in lymph nodes and bones, I am waiting for an appointment for a biopsy to re-evaluate my status. 

 

The question is; am I still positive and have become resistant to the HER2+ treatments, or have I gone negative? 

 

Was told this on 11 December, and after 2 unsuccessful biopsy attempts, I’m waiting for a 3rd appointment. All the while I have a party going on inside me, which scares me. Keep trying to remind myself that progression was spotted early, and as I’m not in any real discomfort, I should be enjoying not having any treatment (only Zometa) but it’s not that easy. 

 

Would be be interested to know whether anyone has changed from positive - negative, or vice versa? 

 

Xx