Member
Posts: 276
Registered: ‎31-07-2017

Re: Chemotherapy after progression

Hi Nicky, I have ended up only having 2 cycles of Kadcyla and in a repeat scan found it’s made no difference at all, and in fact have new sites of progression. So, similarly, I am having a biopsy to check receptors as the doctors are wondering if mets are now HER2- rather than + as my primary was. 

Everything back up in the air again, and a new plan needed. Trying to take one day at a time to stop me overthinking. Xx

Member
Posts: 4
Registered: ‎11-12-2018

Re: Chemotherapy after progression

Hi Nicky,

 

Sorry to hear about you and i wish you recover well.

 

We recenty had her biopsy done for Liver and the results have stated she is 2 Positive. I would be consulting another doc this saturday to have more understanding on the course of treatment to be followed.

 

Thanks,

Rohit Sood

Community Champion
Posts: 4,507
Registered: ‎01-05-2012

Re: Chemotherapy after progression

Hi Rohit

Sorry to hear about your Mum.

I was in a similar situation a few years back having had chemotherapy (docetaxel) with Herceptin and Perjeta. Whilst on the chemo part of the treatment plan my liver mets shrank and responded well.  They stopped responding after whilst on Perjeta and herceptin but I have since found out that the main liver met (which stopped responding to treatment) was actually not HER2+ at all and was in fact triple negative.  It's a long story and I seem to be an unusual case but it might be worth suggesting a liver biopsy to your Mum's oncologist to determine whether her liver mets are in fact HER2+.  If they are not they will not respond to Kadcyla (mine didn't) and in fact she may have bad side effects (as I did) having Kadcyla as it's not the right targetted treatment.  I'm not sure if this helps, and will raise more questions at this point, but I just wanted to say that I had gone down that route of treatment and have since found out it wasn't right for my type of breast cancer.  It is always assumed that the mets are the same receptor status as the primary site but that isnt always the case.

Nicky x

Member
Posts: 4
Registered: ‎11-12-2018

Re: Chemotherapy after progression

​Dear All,

 

Could any of your guide me on below as i am not getting a satisfactory answer from my consulting doc.

 

My mother was diagnosed with Metastatic Breast cancer which has spread into her Liver and Bones. Through recent Chemo sessions her Bone mets have reduced drastically but Liver mets have shown no improvement. Her Chemo had additional drug Perjeta, which initially along with Chemo showed results but when was given individually had no result. 

 

Now the doc has suggested to start with Kadcyla​. She had her first infusion of Kadcyla​ last week ( 7 Dec 18), but due to so called known side effect she is not keeping well. She is experiencing nausea, head ache, body ache, loss in appetite and constipation​.

 

I was reading though the side effects and one of the major one is that it impacts the liver functionality. Since she has Liver mets, will the drug Kadcyla​ be effective for her or will deteriorate her liver to more worse.

 

Your views would be much appreciated. Thanks in advance.

 

Rohit Sood

Highlighted
Community Champion
Posts: 1,046
Registered: ‎21-01-2017

Re: Chemotherapy after progression

[ Edited ]

Hi Butterflyfree, sorry to hear your news, and understand you feeling overwhelmed. I was diagnosed with 4 secondaries in lungs 20 sessions into my rads last year, so had my LWE and chemo to be faced with this. However, I can only say positive things about my treatment. My Onco is wonderful and insists he has a bag of tricks to keep me going. I am also in a great SBC support group in my local Maggies which keeps me laughing with all the semi tragic- comedy stories we tell each other . Some of those girls have been on the go for over 10 years. Not the hand we would have wanted to be dealt, but having been dealt it , that's the hand that needs to be played. Hard at times, I know, so I'm sending a big hug, and wishing you all the best for future treatments. 🍀💐 X 

Member
Posts: 276
Registered: ‎31-07-2017

Re: Chemotherapy after progression

Thank you Helena, you’re so kind. Xx

Community Champion
Posts: 9,633
Registered: ‎16-11-2016

Re: Chemotherapy after progression

Butterflyflyfree

 

Oh mate I am so gutted to hear your news, there is not much I can say other than I am sure you will get loads of support from the ladies on the secondary thread.

 

Sending you lots of love and hugs

 

Helena xxx

Member
Posts: 276
Registered: ‎31-07-2017

Re: Chemotherapy after progression

Hi Leigh, have seen your story and wish you all the best in continuing the treatment that’s working.

 

It’s a interesting one re surgery. I chose to have a mx, as against lx, for my peace of mind and my pathological report showed no cancer cells at all in removed tissue.

But with lymph node involvement at the outset, and a lesion on the sternum the chance of recurrence was always going to be high 🙈 a shock that it has happened so quickly for me though. 

 

Take care xx

Member
Posts: 4
Registered: ‎06-08-2018

Re: Chemotherapy after progression

Hi there,

Sorry to hear your news. I had a similar initial diagnosis in January of this year so am interested to hear your progress x
Member
Posts: 276
Registered: ‎31-07-2017

Chemotherapy after progression

Had felt a bit of a fraud earlier in the year posting on the SBC threads having a solitary sternal lesion (diagnosed simultaneously to primary IDC and lymph node involvement Oct 2017) that reacted well to chemo.  But sadly I now have properly joined the club. Follow up PET/CT scan October 2018 has shown multiple bony lesions in pelvis and collarbone, and widespread lymph nodal lesions. I hadn’t even completed 12m of Herceptin and Pertuzamab. 4x EC, 4x Docetaxol, Mx, SNB, 15x radiotherapy, Letrozole and 16 H&P. 

 

I am gutted, and having spent the past 2 weeks telling all who needed to know, am now feeling completely overwhelmed. 

I start TDM1 (Kadcyla) tomorrow, 3 weekly with Zometa. 

 

This forum was a lifeline to me last time going through treatment, but I am wary of posting on the chemo thread this time for fear of upsetting any of the new primary ladies, so thought this was a better place to start. 

 

Thank you for listening.