It’s difficult for me to say what’s causing the itchy rash under your collarbone.
Skin rashes can have many causes. They are not a common side-effect of Letrozole, although some people have reported getting them.
As E45 and hydrocortisone haven’t helped it might be an idea to see your GP for advice. You could also mention it to your breast care nurse.
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Breast Cancer Care Nurse
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Following a recent mastectomy, I have been taking letrozole for 3 months. Last week a rash appeared under my collarbone - on the right hand side. It is a relatively small patch with some raised areas of skin (macules?) and is both sore and itchy. I have put E45 on it; when that didn’t work, I consulted my local pharmacist who suggested hydrocortisone 1%. This hasn’t worked either.
I think the Letrozole may be causing the rash. Could you let me know what you think please?