Hi, I was on Letrozole for two years then switched to Tamoxifen without a break between. I also have bisphosphonate infusions twice a year.
I worry that Letrozole may have given me better coverage as a post- menopausal 55 year old, but the joint pain side effects had a huge impact on my quality of life.
Tamoxifen seems ‘easier’ on my body but I do think it causes extreme fatigue and mood swings.
it is difficult to know how much is to do with having had cancer, the chemotherapy, the drugs and the intermittent worry about reoccurrence...
I was initially on Letrozole pre lumpectomy, but the pathology results showed that it had only had a clinical effect and not a histological effect on the tumor. Eventually I changed over to Tamoxifen, but was told that I didn't have to wait when switching the meds, just stop Letrozole one day and start on Tamoxifen the next. Now I am worried that I didn't have a break between the meds. I have an oncology review soon so will ask about it then.
I have been taking Tamoxifen (as well as Zoladex injection monthly) for just over a year. When I was initially prescribed it I went to the chemist attached to my doctors (Boots) and asked them what Brand they usually stock. They said "Wockhardt" and I saw my doctor and asked her to put it on the prescription so I always get it. I did have nausea and "heavy legs" for a little while but this went away plus have hot flushes (bearable) plus lots of cramp (controlled with a magnesium tablet). I seem to have a low mood some days but manageable.
I have heard that the TEVA brand is also one of the better ones.
Hope this helps. Michele x
I don't think it's true that there's not a lot of difference, except in the fact that one's talking about small percentages of improvement overall.